With the increasing application of graph learning advanced by deep learning, out-of-distribution (OOD) detection for graph-structured data has become an imperative challenge in the real world. Graph neural networks (GNNs) provide a promising solution for OOD detection. However, GNNs' core message-passing mechanism inherently relies on local neighborhood aggregation, and traditional graph structures only characterize pairwise node relations, failing to capture high-order associations and global patterns. Towards this end, in this paper, we propose a Hypergraph-enhanced graph contrastive learning framework for Graph Out-Of Distribution detection (termed HGOOD). Specifically, we construct two branches to mine graph semantics in a comprehensive manner. On the one hand, we employ a graph feature branch to encode neighborhood interactions via node-level and graph-level contrastive learning. On the other hand, we incorporate the hypergraph-global branch, which adaptively models graphs’ high-order global correlations. Building upon this, we introduce a cross-branch prototype contrast that aligns the captured graph patterns with their cross-branch clustering prototypes to enhance the semantic manifold of the in-distribution (ID) graph. Extensive experiments on benchmark datasets demonstrate that our HGOOD consistently outperforms prior methods. Our code is available at https://anonymous.4open.science/r/HGOOD-CFE2/.