Total variation distance (TV distance) is a fundamental notion of distance between probability distributions. In this work, we introduce and study the problem of computing the TV distance of two product distributions over the domain {0,1}^n. In particular, we establish the following results. 1. The problem of exactly computing the TV distance of two product distributions is #P-complete. This is in stark contrast with other distance measures such as KL, Chi-square, and Hellinger which tensorize over the marginals leading to efficient algorithms. 2. There is a fully polynomial-time deterministic approximation scheme (FPTAS) for computing the TV distance of two product distributions P and Q where Q is the uniform distribution. This result is extended to the case where Q has a constant number of distinct marginals. In contrast, we show that when P and Q are Bayes net distributions the relative approximation of their TV distance is NP-hard.